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Skin lesion, these are when part of the skin has an abnormal growth and look as compared to surrounding part. Psoriasis can be a plaque that results to development of thick red patches on the skin. Psoriasis can develop from pustular that form red bumps. Staph infection, the condition usually comes without any illness which results to development of red fluid-filled and painful bumps on the skin. If infected it may confuse you with spider bites because it resemble it with yellow or white center with a head.